One of the things that freaks me out when watching streams or videos playing it is the number of hotbars people have open. I find it easier when there are only one or two hot bars open including the active one that you are keyboard bashing. I know everyone has a different way to play and it makes for differing approaches on how to kill monsters. So my left hand deals with the numbers and my right deals with movement.
|Easy to remember hot bar.|
|Non combat spells.|
|You should avoid these spells hitting you|
|Layout works for me|
Enjoy you Questing.